› 3u4n

X-ray diffraction
1.98Å resolution

A novel covalently linked insulin dimer

Released:
DOI: 10.2210/pdb3u4n/pdb
PDB entry 3u4n coloured by chain, front view.
PDB entry 3u4n coloured by chain, side view.
PDB entry 3u4n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Novel covalently linked insulin dimer engineered to investigate the function of insulin dimerization.
Vinther TN, Norrman M, Strauss HM, Huus K, Schlein M, Pedersen TÅ, Kjeldsen T, Jensen KJ, Hubálek F
PLoS One 7 e30882 (2012)
PMID: 22363506

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-134182 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chain: A
Molecule details ›
Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chain: B
Molecule details ›
Chain: B
Length: 29 amino acids
Theoretical weight: 3.29 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-53; Coverage: 34%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: I213
Unit cell:
a: 77.942Å b: 77.942Å c: 77.942Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.167 0.217
Expression system: Not provided

Quick links

Citations

2 review citations

[Role of zinc in type 2 diabetes].
Tamaki et al. (2014)
1 more

1 mention without citation

Novel covalently linked insulin dimer engineered to investigate the function of insulin dimerization.
Vinther et al. (2012)