› 3u2p

X-ray diffraction
2.57Å resolution

Crystal structure of N-terminal three extracellular domains of ErbB4/Her4

Released:
DOI: 10.2210/pdb3u2p/pdb
PDB entry 3u2p coloured by chain, front view.
PDB entry 3u2p coloured by chain, side view.
PDB entry 3u2p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether.
Liu P, Bouyain S, Eigenbrot C, Leahy DJ
Protein Sci 21 152-5 (2012)
PMID: 22012915

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172255 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor tyrosine-protein kinase erbB-4 Chain: A
Molecule details ›
Chain: A
Length: 497 amino acids
Theoretical weight: 55.47 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q15303 (Residues: 26-522; Coverage: 39%)
Gene names: ERBB4, HER4
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 5 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 42.17Å b: 85.56Å c: 152.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.192 0.243
Expression system: Cricetulus griseus

Quick links

Citations

2 review citations

Insulin and epidermal growth factor receptor family members share parallel activation mechanisms.
Ferguson et al. (2020)
1 more

3 mentions without citation

Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope.
Orellana et al. (2019)
2 more