› 3tzm

X-ray diffraction
1.7Å resolution

TGF-beta Receptor type 1 in complex with SB431542

Released:
DOI: 10.2210/pdb3tzm/pdb
PDB entry 3tzm coloured by chain, front view.
PDB entry 3tzm coloured by chain, side view.
PDB entry 3tzm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for specificity of TGFβ family receptor small molecule inhibitors.
Ogunjimi AA, Zeqiraj E, Ceccarelli DF, Sicheri F, Wrana JL, David L
Cell Signal 24 476-483 (2012)
PMID: 21983015

Function and Biology Details

Reaction catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153250 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TGF-beta receptor type-1 Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 35.23 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P36897 (Residues: 200-503; Coverage: 65%)
Gene names: ALK5, SKR4, TGFBR1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 085 1 x 085
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 41.771Å b: 77.726Å c: 90.07Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.205
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Structural biology of the TGFβ family.
Goebel et al. (2019)
18 other articles

23 mentions without citation

Development of an ALK2-biased BMP type I receptor kinase inhibitor.
Mohedas et al. (2013)
22 more