› 3tz8

X-ray diffraction
2.7Å resolution

Kinase domain of cSrc in complex with RL104

Released:
DOI: 10.2210/pdb3tz8/pdb
PDB entry 3tz8 coloured by chain, front view.
PDB entry 3tz8 coloured by chain, side view.
PDB entry 3tz8 coloured by chain, top view.
Source organism: Gallus gallus
Entry authors: Gruetter C, Richters A, Rauh D

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.74 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand AQM 2 x AQM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P1
Unit cell:
a: 42Å b: 63.58Å c: 74.51Å
α: 79.08° β: 87.69° γ: 89.88°
R-values:
R R work R free
0.2 0.198 0.258
Expression system: Escherichia coli

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