› 3tlp

X-ray diffraction
2.13Å resolution

Crystal structure of the fourth bromodomain of human poly-bromodomain containing protein 1 (PB1)

Released:
DOI: 10.2210/pdb3tlp/pdb
PDB entry 3tlp coloured by chain, front view.
PDB entry 3tlp coloured by chain, side view.
PDB entry 3tlp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Histone recognition and large-scale structural analysis of the human bromodomain family.
Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S
Cell 149 214-31 (2012)
PMID: 22464331

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183177 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein polybromo-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 150 amino acids
Theoretical weight: 17.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86U86 (Residues: 496-637; Coverage: 8%)
Gene names: BAF180, PB1, PBRM1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand NI 4 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 49.431Å b: 60.22Å c: 109.907Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.249
Expression system: Escherichia coli BL21(DE3)

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Citations

245 review citations

Modification of enhancer chromatin: what, how, and why?
Calo et al. (2013)
244 more

4 mentions without citation

Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites.
Vidler et al. (2012)
3 more