3tho

X-ray diffraction
2.61Å resolution

Crystal structure of Mre11:Rad50 in its ATP/ADP bound state

Released:
Source organism: Thermotoga maritima

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
PDBe Complex ID:
PDB-CPX-194846 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA double-strand break repair Rad50 ATPase Chain: A
Molecule details ›
Chain: A
Length: 382 amino acids
Theoretical weight: 43.08 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9X1X1 (Residues: 1-190, 686-852; Coverage: 42%)
Gene names: TM_1636, rad50
Sequence domains:
Structure domains:
DNA double-strand break repair protein Mre11 Chain: B
Molecule details ›
Chain: B
Length: 379 amino acids
Theoretical weight: 43.97 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9X1X0 (Residues: 7-385; Coverage: 98%)
Gene names: TM_1635, mre11
Sequence domains: Calcineurin-like phosphoesterase
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3221
Unit cell:
a: 121.772Å b: 121.772Å c: 135.126Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.242
Expression system: Escherichia coli