› 3tha

X-ray diffraction
2.37Å resolution

Tryptophan synthase subunit alpha from Campylobacter jejuni.

Released:
DOI: 10.2210/pdb3tha/pdb
PDB entry 3tha coloured by chain, front view.
PDB entry 3tha coloured by chain, side view.
PDB entry 3tha coloured by chain, top view.
Source organism: Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Entry authors: Osipiuk J, Gu M, Kwon K, Anderson WF, Joachimiak A, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Reaction catalysed: 
(1a) 1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192900 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptophan synthase alpha chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 252 amino acids
Theoretical weight: 28.46 KDa
Source organism: Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9PIF1 (Residues: 1-249; Coverage: 100%)
Gene names: Cj0349, trpA
Sequence domains: Tryptophan synthase alpha chain
Structure domains: Aldolase class I

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3121
Unit cell:
a: 91.969Å b: 91.969Å c: 120.02Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.216 0.263
Expression system: Escherichia coli BL21(DE3)

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