› 3sxs

X-ray diffraction
1.89Å resolution

Crystal structure of BMX non-receptor tyrosine kinase complexed with PP2

Released:
DOI: 10.2210/pdb3sxs/pdb
PDB entry 3sxs coloured by chain, front view.
PDB entry 3sxs coloured by chain, side view.
PDB entry 3sxs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray crystal structure of bone marrow kinase in the x chromosome: a Tec family kinase.
Muckelbauer J, Sack JS, Ahmed N, Burke J, Chang CY, Gao M, Tino J, Xie D, Tebben AJ
Chem Biol Drug Des 78 739-48 (2011)
PMID: 21883956

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156424 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytoplasmic tyrosine-protein kinase BMX Chain: A
Molecule details ›
Chain: A
Length: 268 amino acids
Theoretical weight: 31.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P51813 (Residues: 411-675; Coverage: 39%)
Gene name: BMX
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PP2 1 x PP2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2221
Unit cell:
a: 55.954Å b: 89.68Å c: 117.015Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.179 0.209
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

BMX and its role in inflammation, cardiovascular disease, and cancer.
Cenni et al. (2012)
2 more

6 mentions without citation

Developing irreversible inhibitors of the protein kinase cysteinome.
Liu et al. (2013)
5 more