› 3s9o

X-ray diffraction
2.6Å resolution

The Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase showing N-terminal interactions in cis

Released:
DOI: 10.2210/pdb3s9o/pdb
PDB entry 3s9o coloured by chain, front view.
PDB entry 3s9o coloured by chain, side view.
PDB entry 3s9o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational dynamics of the focal adhesion targeting domain control specific functions of focal adhesion kinase in cells.
Kadaré G, Gervasi N, Brami-Cherrier K, Blockus H, El Messari S, Arold ST, Girault JA
J Biol Chem 290 478-91 (2015)
PMID: 25391654

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 164 amino acids
Theoretical weight: 18.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q05397 (Residues: 891-1052; Coverage: 15%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Focal adhesion targeting region
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NA 2 x NA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2221
Unit cell:
a: 89.918Å b: 223.983Å c: 98.015Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.233 0.287
Expression system: Escherichia coli

Quick links

Citations

7 review citations

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review.
Zhou et al. (2019)
6 more

2 mentions without citation

Targeting Focal Adhesion Kinase Using Inhibitors of Protein-Protein Interactions.
Mousson et al. (2018)
1 more