› 3rvc

X-ray diffraction
1.8Å resolution

Effector domain of NS1 from influenza A/PR/8/34 containing a W187A mutation

Released:
DOI: 10.2210/pdb3rvc/pdb
PDB entry 3rvc coloured by chain, front view.
PDB entry 3rvc coloured by chain, side view.
PDB entry 3rvc coloured by chain, top view.
Source organism: Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Primary publication:
Conservation of a crystallographic interface suggests a role for β-sheet augmentation in influenza virus NS1 multifunctionality.
Kerry PS, Long E, Taylor MA, Russell RJ
Acta Crystallogr Sect F Struct Biol Cryst Commun 67 858-61 (2011)
PMID: 21821881

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137075 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-structural protein 1 Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 16.88 KDa
Source organism: Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Expression system: Escherichia coli
UniProt:
  • Canonical: P03496 (Residues: 79-230; Coverage: 66%)
Gene name: NS
Sequence domains: Influenza non-structural protein (NS1)
Structure domains: Influenza virus non-structural protein, effector domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2221
Unit cell:
a: 31.992Å b: 102.773Å c: 67.397Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.195 0.245
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Conformational plasticity of the influenza A virus NS1 protein.
Hale BG. (2014)
2 more

3 mentions without citation

Analysis of the genetic diversity of influenza A viruses using next-generation DNA sequencing.
Van den Hoecke et al. (2015)
2 more