› 3rv5

X-ray diffraction
2.2Å resolution

Crystal structure of human cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid

Released:
DOI: 10.2210/pdb3rv5/pdb
PDB entry 3rv5 coloured by chain, front view.
PDB entry 3rv5 coloured by chain, side view.
PDB entry 3rv5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid reveals novel conformation.
Li AY, Lee J, Borek D, Otwinowski Z, Tibbits GF, Paetzel M
J Mol Biol 413 699-711 (2011)
PMID: 21920370

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-159088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, slow skeletal and cardiac muscles Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 89 amino acids
Theoretical weight: 10.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P63316 (Residues: 1-89; Coverage: 55%)
Gene names: TNNC, TNNC1
Sequence domains: EF-hand domain pair

Ligands and Environments

3 bound ligands:
Ligand CD 21 x CD
Ligand DXC 5 x DXC
Ligand CA 3 x CA
1 modified residue:
Ligand MSE 28 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P21212
Unit cell:
a: 51.844Å b: 81.783Å c: 100.469Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.225 0.281
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 citation in other articles

Dynamics and calcium association to the N-terminal regulatory domain of human cardiac troponin C: a multiscale computational study.
Lindert et al. (2012)
3 more

1 mention without citation

Crystal structure of cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid reveals novel conformation.
Li et al. (2011)