› 3rtw

X-ray diffraction
2.1Å resolution

Nitrowillardiine bound to the ligand binding domain of GluA2

Released:
DOI: 10.2210/pdb3rtw/pdb
PDB entry 3rtw coloured by chain, front view.
PDB entry 3rtw coloured by chain, side view.
PDB entry 3rtw coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanisms of modal activation of GluA3 receptors.
Poon K, Ahmed AH, Nowak LM, Oswald RE
Mol Pharmacol 80 49-59 (2011)
PMID: 21464198

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 258 amino acids
Theoretical weight: 28.84 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 414-527, 653-794; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand NWD 3 x NWD
Ligand ZN 5 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Unit cell:
a: 48.077Å b: 114.102Å c: 165.048Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.259
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Functional insights from glutamate receptor ion channel structures.
Kumar et al. (2013)
7 more

6 mentions without citation

Size matters in activation/inhibition of ligand-gated ion channels.
Du et al. (2012)
5 more