› 3qyt

X-ray diffraction
2.8Å resolution

Diferric bound human serum transferrin

Released:
DOI: 10.2210/pdb3qyt/pdb
PDB entry 3qyt coloured by chain, front view.
PDB entry 3qyt coloured by chain, side view.
PDB entry 3qyt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe.
Yang N, Zhang H, Wang M, Hao Q, Sun H
Sci Rep 2 999 (2012)
PMID: 23256035

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotransferrin Chain: A
Molecule details ›
Chain: A
Length: 679 amino acids
Theoretical weight: 75.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02787 (Residues: 20-698; Coverage: 100%)
Gene names: PRO1400, TF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

4 bound ligands:
Ligand FE 2 x FE
Ligand CO3 2 x CO3
Ligand NAG 2 x NAG
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 73.845Å b: 90.435Å c: 112.299Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.206 0.275

Quick links

Citations

5 review citations

Current and potential applications of bismuth-based drugs.
Keogan et al. (2014)
4 more

10 mentions without citation

Using X-ray Diffraction Techniques for Biomimetic Drug Development, Formulation, and Polymorphic Characterization.
Rodríguez et al. (2020)
9 more