› 3qgz

X-ray diffraction
1.1Å resolution

Re-investigated high resolution crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from rabbit complexed with adenosine

Released:
DOI: 10.2210/pdb3qgz/pdb
PDB entry 3qgz coloured by chain, front view.
PDB entry 3qgz coloured by chain, side view.
PDB entry 3qgz coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
High-resolution X-ray structure of the rabbit histidine triad nucleotide-binding protein 1 (rHINT1)-adenosine complex at 1.10 Å resolution.
Dolot R, Ozga M, Krakowiak A, Nawrot B
Acta Crystallogr D Biol Crystallogr 67 601-7 (2011)
PMID: 21697598

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160462 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine 5'-monophosphoramidase HINT1 Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 13.71 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P80912 (Residues: 1-126; Coverage: 100%)
Gene names: HINT, HINT1
Sequence domains: HIT domain
Structure domains: HIT-like

Ligands and Environments

1 bound ligand:
Ligand ADN 1 x ADN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: P43212
Unit cell:
a: 39.747Å b: 39.747Å c: 141.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.144 0.142 0.168
Expression system: Escherichia coli BL21

Quick links

Citations

2 citation in other articles

Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia.
Zimoń et al. (2012)
1 more