› 3qbq

X-ray diffraction
2.5Å resolution

Crystal structure of extracellular domains of mouse RANK-RANKL complex

Released:
DOI: 10.2210/pdb3qbq/pdb
PDB entry 3qbq coloured by chain, front view.
PDB entry 3qbq coloured by chain, side view.
PDB entry 3qbq coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure-based development of a receptor activator of nuclear factor-kappaB ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis.
Ta HM, Nguyen GT, Jin HM, Choi J, Park H, Kim N, Hwang HY, Kim KK
Proc Natl Acad Sci U S A 107 20281-6 (2010)
PMID: 21059944

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128661 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor ligand superfamily member 11, soluble form Chains: A, C
Molecule details ›
Chains: A, C
Length: 160 amino acids
Theoretical weight: 17.86 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O35235 (Residues: 157-316; Coverage: 51%)
Gene names: Opgl, Rankl, Tnfsf11, Trance
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 11A Chains: B, D
Molecule details ›
Chains: B, D
Length: 170 amino acids
Theoretical weight: 18.67 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O35305 (Residues: 32-201; Coverage: 29%)
Gene names: Rank, Tnfrsf11a
Sequence domains:
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P3
Unit cell:
a: 120.86Å b: 120.86Å c: 93.425Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.227 0.249
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Osteopetrosis: genetics, treatment and new insights into osteoclast function.
Sobacchi et al. (2013)
13 more

4 mentions without citation

Design of a RANK-Mimetic Peptide Inhibitor of Osteoclastogenesis with Enhanced RANKL-Binding Affinity.
Hur et al. (2016)
3 more