› 3q41

X-ray diffraction
3.4Å resolution

Crystal structure of the GluN1 N-terminal domain (NTD)

Released:
DOI: 10.2210/pdb3q41/pdb
PDB entry 3q41 coloured by chain, front view.
PDB entry 3q41 coloured by chain, side view.
PDB entry 3q41 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Separation of domain contacts is required for heterotetrameric assembly of functional NMDA receptors.
Farina AN, Blain KY, Maruo T, Kwiatkowski W, Choe S, Nakagawa T
J Neurosci 31 3565-79 (2011)
PMID: 21389213

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152908 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, NMDA 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 384 amino acids
Theoretical weight: 42.68 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P35439 (Residues: 21-393; Coverage: 41%)
Gene names: Grin1, Nmdar1
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:
Ligand NAG 15 x NAG
Ligand CL 8 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P3121
Unit cell:
a: 164.679Å b: 164.679Å c: 147.258Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.232 0.229 0.279
Expression system: Homo sapiens

Quick links

Citations

15 review citations

Autoantibodies associated with diseases of the CNS: new developments and future challenges.
Vincent et al. (2011)
14 more

11 mentions without citation

New advances in NMDA receptor pharmacology.
Ogden et al. (2011)
10 more