› 3q10

X-ray diffraction
1.83Å resolution

Pantoate-beta-alanine ligase from Yersinia pestis

Released:
DOI: 10.2210/pdb3q10/pdb
PDB entry 3q10 coloured by chain, front view.
PDB entry 3q10 coloured by chain, side view.
PDB entry 3q10 coloured by chain, top view.
Source organism: Yersinia pestis
Entry authors: Osipiuk J, Maltseva N, Kwon K, Anderson WF, Joachimiak A, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187188 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pantothenate synthetase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 287 amino acids
Theoretical weight: 32.08 KDa
Source organism: Yersinia pestis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8ZBK7 (Residues: 1-284; Coverage: 100%)
Gene names: YPO3402, YP_0283, panC, y0785
Sequence domains: Pantoate-beta-alanine ligase
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand AMP 4 x AMP
Ligand GOL 5 x GOL
Ligand IMD 1 x IMD
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P1
Unit cell:
a: 44.809Å b: 77.241Å c: 98.462Å
α: 101.33° β: 94.91° γ: 94.37°
R-values:
R R work R free
0.176 0.174 0.211
Expression system: Escherichia coli BL21(DE3)

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