› 3pvo

X-ray diffraction
3Å resolution

Monoclinic form of Human C-Reactive Protein

Released:
DOI: 10.2210/pdb3pvo/pdb
PDB entry 3pvo coloured by chain, front view.
PDB entry 3pvo coloured by chain, side view.
PDB entry 3pvo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A staggered decameric assembly of human C-reactive protein stabilized by zinc ions revealed by X-ray crystallography.
Guillon C, Bigouagou UM, Folio C, Jeannin P, Delneste Y, Gouet P
Protein Pept Lett 22 248-55 (2014)
PMID: 25552313

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136120 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-reactive protein Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
Length: 206 amino acids
Theoretical weight: 23.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02741 (Residues: 19-224; Coverage: 100%)
Gene names: CRP, PTX1
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand CA 40 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P21
Unit cell:
a: 97.6Å b: 143.2Å c: 161.2Å
α: 90° β: 89.7° γ: 90°
R-values:
R R work R free
0.229 0.227 0.285
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Anti-Pentraxin Antibodies in Autoimmune Diseases: Bystanders or Pathophysiological Actors?
Brilland et al. (2020)
1 more

3 mentions without citation

Conformational folding and disulfide bonding drive distinct stages of protein structure formation.
Lv et al. (2018)
2 more