› 3prg

X-ray diffraction
2.9Å resolution

LIGAND BINDING DOMAIN OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR

Released:
DOI: 10.2210/pdb3prg/pdb
PDB entry 3prg coloured by chain, front view.
PDB entry 3prg coloured by chain, side view.
PDB entry 3prg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma.
Uppenberg J, Svensson C, Jaki M, Bertilsson G, Jendeberg L, Berkenstam A
J Biol Chem 273 31108-12 (1998)
PMID: 9813012

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 278 amino acids
Theoretical weight: 31.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 229-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P43212
Unit cell:
a: 67.25Å b: 67.25Å c: 156.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.209 0.271
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

42 review citations

Nuclear hormone receptors and gene expression.
Aranda et al. (2001)
41 more

6 mentions without citation

PPARĪ³ Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue.
Choi et al. (2016)
5 more