› 3pan

X-ray diffraction
2.63Å resolution

The crystal structure of adenosine deaminase with hypoxanthine bound from Pseudomonas aeruginosa

Released:
DOI: 10.2210/pdb3pan/pdb
PDB entry 3pan coloured by chain, front view.
PDB entry 3pan coloured by chain, side view.
PDB entry 3pan coloured by chain, top view.
Source organism: Pseudomonas aeruginosa
Entry authors: Zhang Z, Burley SK, Swaminathan S, New York SGX Research Center for Structural Genomics (NYSGXRC)

Function and Biology Details

Reaction catalysed: 
Adenine + H(2)O = hypoxanthine + NH(3)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191478 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenine deaminase Chains: A, B
Molecule details ›
Chains: A, B
Length: 326 amino acids
Theoretical weight: 37.66 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9I6Y4 (Residues: 2-316; Coverage: 100%)
Gene name: PA0148
Sequence domains: Adenosine deaminase
Structure domains: Metal-dependent hydrolases

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand HPA 2 x HPA
1 modified residue:
Ligand MSE 10 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P212121
Unit cell:
a: 44.698Å b: 74.146Å c: 178.007Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.192 0.253
Expression system: Escherichia coli BL21(DE3)

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