› 3ont

X-ray diffraction
2.65Å resolution

The Crystal Structure of Spot14, a modulator of lipogenesis

Released:
DOI: 10.2210/pdb3ont/pdb
PDB entry 3ont coloured by chain, front view.
PDB entry 3ont coloured by chain, side view.
PDB entry 3ont coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of Spot 14, a modulator of fatty acid synthesis.
Colbert CL, Kim CW, Moon YA, Henry L, Palnitkar M, McKean WB, Fitzgerald K, Deisenhofer J, Horton JD, Kwon HJ
Proc Natl Acad Sci U S A 107 18820-5 (2010)
PMID: 20952656

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178929 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroid hormone-inducible hepatic protein Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 17.54 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q62264 (Residues: 1-150; Coverage: 100%)
Gene names: S14, Thrsp
Sequence domains: Thyroid hormone-inducible hepatic protein Spot 14
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: I432
Unit cell:
a: 144.951Å b: 144.951Å c: 144.951Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.223 0.249
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria.
Gao et al. (2012)
11 more

2 mentions without citation

Crystal structure of Spot 14, a modulator of fatty acid synthesis.
Colbert et al. (2010)
1 more