› 3okt

X-ray diffraction
2.3Å resolution

Mouse Plexin A2, extracellular domains 1-4

Released:
DOI: 10.2210/pdb3okt/pdb
PDB entry 3okt coloured by chain, front view.
PDB entry 3okt coloured by chain, side view.
PDB entry 3okt coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of semaphorin-plexin signalling.
Janssen BJ, Robinson RA, Pérez-Brangulí F, Bell CH, Mitchell KJ, Siebold C, Jones EY
Nature 467 1118-22 (2010)
PMID: 20877282

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-159714 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plexin-A2 Chain: A
Molecule details ›
Chain: A
Length: 681 amino acids
Theoretical weight: 75.93 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P70207 (Residues: 35-703; Coverage: 36%)
Gene names: Kiaa0463, Plxna2
Sequence domains:
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

4 bound ligands:
Ligand NAG 5 x NAG
Ligand CL 2 x CL
Ligand NA 1 x NA
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 157.86Å b: 92.903Å c: 62.904Å
α: 90° β: 102.87° γ: 90°
R-values:
R R work R free
0.199 0.196 0.251
Expression system: Homo sapiens

Quick links

Citations

50 review citations

Getting neural circuits into shape with semaphorins.
Pasterkamp RJ. (2012)
49 more

6 mentions without citation

Function of members of the neuropilin family as essential pleiotropic cell surface receptors.
Parker et al. (2012)
5 more