› 3nv3

X-ray diffraction
1.57Å resolution

Crystal structure of human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide

Released:
DOI: 10.2210/pdb3nv3/pdb
PDB entry 3nv3 coloured by chain, front view.
PDB entry 3nv3 coloured by chain, side view.
PDB entry 3nv3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray structures of human galectin-9 C-terminal domain in complexes with a biantennary oligosaccharide and sialyllactose.
Yoshida H, Teraoka M, Nishi N, Nakakita S, Nakamura T, Hirashima M, Kamitori S
J Biol Chem 285 36969-76 (2010)
PMID: 20861009

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126137 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-9 Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 15.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00182 (Residues: 218-355; Coverage: 39%)
Gene name: LGALS9
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: MAN, NAG, GAL
Carbohydrate polymer
1 bound ligand:
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P63
Unit cell:
a: 71.003Å b: 71.003Å c: 49.741Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.188 0.212
Expression system: Escherichia coli BL21(DE3)

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Citations

12 review citations

Multifarious roles of sialic acids in immunity.
Varki et al. (2012)
11 more

4 mentions without citation

New targets for HIV drug discovery.
Puhl et al. (2019)
3 more