› 3nd5

X-ray diffraction
2.3Å resolution

Crystal structure of phosphopantetheine adenylyltransferase (PPAT) from Enterococcus faecalis

Released:
DOI: 10.2210/pdb3nd5/pdb
PDB entry 3nd5 coloured by chain, front view.
PDB entry 3nd5 coloured by chain, side view.
PDB entry 3nd5 coloured by chain, top view.
Source organism: Enterococcus faecalis
Primary publication:
Crystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheine.
Yoon HJ, Kang JY, Mikami B, Lee HH, Suh SW
Mol Cells 32 431-5 (2011)
PMID: 21912874

Function and Biology Details

Reaction catalysed: 
ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182773 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphopantetheine adenylyltransferase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 171 amino acids
Theoretical weight: 19.77 KDa
Source organism: Enterococcus faecalis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q831P9 (Residues: 1-163; Coverage: 100%)
Gene names: EF_2451, coaD
Sequence domains: Cytidylyltransferase-like
Structure domains: HUPs

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P212121
Unit cell:
a: 110.198Å b: 125.683Å c: 125.821Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.249
Expression system: Escherichia coli

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Citations

1 review citation

Structural Biology and the Design of New Therapeutics: From HIV and Cancer to Mycobacterial Infections: A Paper Dedicated to John Kendrew.
Thomas et al. (2017)
5 other articles

1 mention without citation

Crystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheine.
Yoon et al. (2011)