› 3n6v

X-ray diffraction
3.2Å resolution

Structure of the GluA2 NTD-dimer interface mutant, T78A

Released:
DOI: 10.2210/pdb3n6v/pdb
PDB entry 3n6v coloured by chain, front view.
PDB entry 3n6v coloured by chain, side view.
PDB entry 3n6v coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers.
Rossmann M, Sukumaran M, Penn AC, Veprintsev DB, Babu MM, Greger IH
EMBO J 30 959-71 (2011)
PMID: 21317873

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 374 amino acids
Theoretical weight: 42.28 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P19491 (Residues: 27-400; Coverage: 43%)
Gene names: GluA2, Glur2, Gria2
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 64.21Å b: 120.15Å c: 360.81Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.235 0.265
Expression system: Spodoptera frugiperda

Quick links

Citations

25 review citations

Synaptic AMPA receptor composition in development, plasticity and disease.
Henley et al. (2016)
24 more

1 mention without citation

Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers.
Rossmann et al. (2011)