› 3mjk

X-ray diffraction
2.4Å resolution

Structure of a growth factor precursor

Released:
DOI: 10.2210/pdb3mjk/pdb
PDB entry 3mjk coloured by chain, front view.
PDB entry 3mjk coloured by chain, side view.
PDB entry 3mjk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.
Shim AH, Liu H, Focia PJ, Chen X, Lin PC, He X
Proc Natl Acad Sci U S A 107 11307-12 (2010)
PMID: 20534510

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137400 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Platelet-derived growth factor subunit A Chains: A, B, E, F, X, Y
Molecule details ›
Chains: A, B, E, F, X, Y
Length: 169 amino acids
Theoretical weight: 19.4 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04085 (Residues: 21-181; Coverage: 84%)
Gene names: PDGF1, PDGFA
Sequence domains:
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 50.841Å b: 119.208Å c: 146.712Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.225 0.276
Expression system: Spodoptera frugiperda

Quick links

Citations

26 review citations

Structural Biology and Evolution of the TGF-β Family.
Hinck et al. (2016)
25 more

5 mentions without citation

Platelet-derived growth factors and their receptors: structural and functional perspectives.
Chen et al. (2013)
4 more