› 3mao

X-ray diffraction
1.42Å resolution

Crystal Structure of Human Methionine-R-Sulfoxide Reductase B1 (MsrB1)

Released:
DOI: 10.2210/pdb3mao/pdb
PDB entry 3mao coloured by chain, front view.
PDB entry 3mao coloured by chain, side view.
PDB entry 3mao coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chaikuad A, Shafqat N, Yue WW, Savitsky P, Krojer T, Ugochukwu E, Muniz JRC, Pike ACW, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H(2)O = L-methionine (R)-S-oxide + thioredoxin
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192790 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methionine-R-sulfoxide reductase B1 Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZV6 (Residues: 10-112; Coverage: 89%)
Gene names: HSPC270, MSRB1, SEPX1
Sequence domains: SelR domain
Structure domains: Peptide methionine sulfoxide reductase.

Ligands and Environments

3 bound ligands:
Ligand FE 1 x FE
Ligand NA 2 x NA
Ligand MLI 2 x MLI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 34.054Å b: 47.473Å c: 57.809Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.142 0.14 0.17
Expression system: Escherichia coli

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