› 3lmk

X-ray diffraction
2.44Å resolution

Ligand Binding Domain of Metabotropoc glutamate receptor mGluR5 complexed with glutamate

Released:
DOI: 10.2210/pdb3lmk/pdb
PDB entry 3lmk coloured by chain, front view.
PDB entry 3lmk coloured by chain, side view.
PDB entry 3lmk coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dobrovetsky E, Khutoreskaya G, Seitova A, Cossar D, Edwards AM, Arrowsmith CH, Bountra C, Weigelt J, Bochkarev A, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154410 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 492 amino acids
Theoretical weight: 55.44 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P41594 (Residues: 18-505; Coverage: 41%)
Gene names: GPRC1E, GRM5, MGLUR5
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:
Ligand NAG 2 x NAG
Ligand GLU 2 x GLU
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 71.875Å b: 98.346Å c: 155.239Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.281
Expression system: unidentified baculovirus

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