› 3l8j

X-ray diffraction
3.05Å resolution

Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity

Released:
DOI: 10.2210/pdb3l8j/pdb
PDB entry 3l8j coloured by chain, front view.
PDB entry 3l8j coloured by chain, side view.
PDB entry 3l8j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity.
Li X, Zhang R, Zhang H, He Y, Ji W, Min W, Boggon TJ
J Biol Chem 285 24099-107 (2010)
PMID: 20489202

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189740 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death protein 10 Chain: A
Molecule details ›
Chain: A
Length: 202 amino acids
Theoretical weight: 23.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BUL8 (Residues: 14-212; Coverage: 94%)
Gene names: CCM3, PDCD10, TFAR15
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P4122
Unit cell:
a: 77.445Å b: 77.445Å c: 108.629Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.279 0.278 0.293
Expression system: Escherichia coli

Quick links

Citations

22 review citations

STRIPAK complexes: structure, biological function, and involvement in human diseases.
Hwang et al. (2014)
21 more

3 mentions without citation

Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity.
Li et al. (2010)
2 more