› 3ks9

X-ray diffraction
1.9Å resolution

Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist

Released:
DOI: 10.2210/pdb3ks9/pdb
PDB entry 3ks9 coloured by chain, front view.
PDB entry 3ks9 coloured by chain, side view.
PDB entry 3ks9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dobrovetsky E, Khutoreskaya G, Seitova A, Cossar D, Edwards AM, Arrowsmith CH, Bountra C, Weigelt J, Bochkarev A, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171616 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 496 amino acids
Theoretical weight: 55.69 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q13255 (Residues: 28-518; Coverage: 42%)
Gene names: GPRC1A, GRM1, MGLUR1
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:
Ligand Z99 2 x Z99
Ligand MG 2 x MG
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 79.23Å b: 96.546Å c: 97.545Å
α: 90° β: 106.67° γ: 90°
R-values:
R R work R free
0.207 0.206 0.241
Expression system: unidentified baculovirus

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