3kas

X-ray diffraction
2.4Å resolution

Machupo virus GP1 bound to human transferrin receptor 1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-136220 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Transferrin receptor protein 1, serum form Chain: A
Molecule details ›
Chain: A
Length: 640 amino acids
Theoretical weight: 71.81 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P02786 (Residues: 121-760; Coverage: 84%)
Gene name: TFRC
Sequence domains:
Structure domains:
Pre-glycoprotein polyprotein GP complex Chain: B
Molecule details ›
Chain: B
Length: 162 amino acids
Theoretical weight: 18.62 KDa
Source organism: Mammarenavirus machupoense
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8AZ57 (Residues: 83-244; Coverage: 33%)
Gene name: GPC
Sequence domains: Arenavirus glycoprotein

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2221
Unit cell:
a: 143.951Å b: 170.228Å c: 98.471Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.189 0.238
Expression systems:
  • Cricetulus griseus
  • Spodoptera frugiperda