› 3k40

X-ray diffraction
1.75Å resolution

Crystal structure of Drosophila 3,4-dihydroxyphenylalanine decarboxylase

Released:
DOI: 10.2210/pdb3k40/pdb
PDB entry 3k40 coloured by chain, front view.
PDB entry 3k40 coloured by chain, side view.
PDB entry 3k40 coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase.
Han Q, Ding H, Robinson H, Christensen BM, Li J
PLoS One 5 e8826 (2010)
PMID: 20098687

Function and Biology Details

Reaction catalysed: 
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138332 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aromatic-L-amino-acid decarboxylase Chains: A, B
Molecule details ›
Chains: A, B
Length: 475 amino acids
Theoretical weight: 53.87 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05031 (Residues: 36-510; Coverage: 93%)
Gene names: CG10697, Ddc
Sequence domains: Pyridoxal-dependent decarboxylase conserved domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
1 modified residue:
Ligand LLP 2 x LLP

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21212
Unit cell:
a: 105.809Å b: 108.597Å c: 86.294Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.197 0.226
Expression system: Escherichia coli BL21(DE3)

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Citations

6 review citations

Trace Amines and Their Receptors.
Gainetdinov et al. (2018)
5 more

4 mentions without citation

Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase.
Han et al. (2010)
3 more