› 3k2a

X-ray diffraction
1.95Å resolution

Crystal structure of the homeobox domain of human homeobox protein Meis2

Released:
DOI: 10.2210/pdb3k2a/pdb
PDB entry 3k2a coloured by chain, front view.
PDB entry 3k2a coloured by chain, side view.
PDB entry 3k2a coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lam R, Soloveychik M, Battaile KP, Romanov V, Lam K, Beletskaya I, Gordon E, Pai EF, Chirgadze NY

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo hexadecamer
Assembly name:
PDBe Complex ID:
PDB-CPX-127117 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homeobox protein Meis2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 67 amino acids
Theoretical weight: 7.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14770 (Residues: 281-345; Coverage: 14%)
Gene names: MEIS2, MRG1
Sequence domains: Homeobox KN domain
Structure domains: Homeodomain-like

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand ACT 2 x ACT
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: I422
Unit cell:
a: 113.597Å b: 113.597Å c: 50.251Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.215 0.239
Expression system: Escherichia coli

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