› 3jxi

X-ray diffraction
2.3Å resolution

Crystal structure of the chicken TRPV4 ankyrin repeat domain

Released:
DOI: 10.2210/pdb3jxi/pdb
PDB entry 3jxi coloured by chain, front view.
PDB entry 3jxi coloured by chain, side view.
PDB entry 3jxi coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C.
Landouré G, Zdebik AA, Martinez TL, Burnett BG, Stanescu HC, Inada H, Shi Y, Taye AA, Kong L, Munns CH, Choo SS, Phelps CB, Paudel R, Houlden H, Ludlow CL, Caterina MJ, Gaudet R, Kleta R, Fischbeck KH, Sumner CJ
Nat Genet 42 170-4 (2010)
PMID: 20037586

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103372 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 260 amino acids
Theoretical weight: 29.48 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A1D5PXA5 (Residues: 133-382; Coverage: 29%)
Gene name: TRPV4
Sequence domains: Ankyrin repeat
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 105.259Å b: 48.119Å c: 133.891Å
α: 90° β: 101.89° γ: 90°
R-values:
R R work R free
0.204 0.203 0.243
Expression system: Escherichia coli

Quick links

Citations

81 review citations

The transient receptor potential family of ion channels.
Nilius et al. (2011)
80 more

3 mentions without citation

Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C.
Landouré et al. (2010)
2 more