3jac

Electron Microscopy
4.8Å resolution

Cryo-EM study of a channel

Released:
Source organism: Mus musculus
Primary publication:
Architecture of the mammalian mechanosensitive Piezo1 channel.
Nature 527 64-9 (2015)
PMID: 26390154
Related structures: EMD-6343

Function and Biology Details

Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
PDBe Complex ID:
PDB-CPX-122833 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Piezo-type mechanosensitive ion channel component 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 2553 amino acids
Theoretical weight: 234.83 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: E2JF22 (Residues: 1961-2547; Coverage: 23%)
Gene names: Fam38a, Piezo1
Sequence domains: Piezo non-specific cation channel, R-Ras-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.8Å
Relevant EMDB volumes: EMD-6343
Expression system: Homo sapiens