› 3iyp

Electron Microscopy
7.2Å resolution

The Interaction of Decay-accelerating Factor with Echovirus 7

Released:
DOI: 10.2210/pdb3iyp/pdb
PDB entry 3iyp coloured by chain, front view.
PDB entry 3iyp coloured by chain, side view.
PDB entry 3iyp coloured by chain, top view.
Source organisms:
Primary publication:
Interaction of decay-accelerating factor with echovirus 7.
Plevka P, Hafenstein S, Harris KG, Cifuente JO, Zhang Y, Bowman VD, Chipman PR, Bator CM, Lin F, Medof ME, Rossmann MG
J Virol 84 12665-74 (2010)
PMID: 20881044
Related structures: EMD-5179

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 300-mer (preferred)
PDBe Complex ID:
PDB-CPX-139975 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Capsid protein Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.31 KDa
Source organism: Echovirus E7
UniProt:
  • Canonical: Q9QP24 (Residues: 1-292; Coverage: 100%)
Gene name: VP1
Sequence domains: picornavirus capsid protein
Polyprotein Chain: B
Molecule details ›
Chain: B
Length: 238 amino acids
Theoretical weight: 26.23 KDa
Source organism: Echovirus E7
UniProt:
  • Canonical: Q6W9E5 (Residues: 331-568; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Polyprotein Chain: C
Molecule details ›
Chain: C
Length: 260 amino acids
Theoretical weight: 29.07 KDa
Source organism: Echovirus E7
UniProt:
  • Canonical: Q6W9E5 (Residues: 71-330; Coverage: 12%)
Sequence domains: picornavirus capsid protein
Polyprotein Chain: D
Molecule details ›
Chain: D
Length: 70 amino acids
Theoretical weight: 7.6 KDa
Source organism: Echovirus E7
UniProt:
  • Canonical: Q91QV1 (Residues: 1-70; Coverage: 48%)
Sequence domains: Picornavirus coat protein (VP4)
Complement decay-accelerating factor Chain: F
Molecule details ›
Chain: F
Length: 381 amino acids
Theoretical weight: 41.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08174 (Residues: 1-381; Coverage: 100%)
Gene names: CD55, CR, DAF
Sequence domains: Sushi repeat (SCR repeat)

Ligands and Environments

1 bound ligand:
Ligand DAO 1 x DAO
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 7.2Å
Relevant EMDB volumes: EMD-5179

Quick links

Citations

4 review citations

Neurotropic Enterovirus Infections in the Central Nervous System.
Huang et al. (2015)
3 more

3 mentions without citation

Interaction of decay-accelerating factor with echovirus 7.
Plevka et al. (2010)
2 more