› 3iu6

X-ray diffraction
1.79Å resolution

Crystal structure of the sixth bromodomain of human poly-bromodomain containing protein 1 (PB1)

Released:
DOI: 10.2210/pdb3iu6/pdb
PDB entry 3iu6 coloured by chain, front view.
PDB entry 3iu6 coloured by chain, side view.
PDB entry 3iu6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Histone recognition and large-scale structural analysis of the human bromodomain family.
Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S
Cell 149 214-31 (2012)
PMID: 22464331

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183177 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein polybromo-1 Chain: A
Molecule details ›
Chain: A
Length: 147 amino acids
Theoretical weight: 17.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86U86 (Residues: 773-914; Coverage: 8%)
Gene names: BAF180, PB1, PBRM1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand EDO 3 x EDO
Ligand ZN 1 x ZN
1 modified residue:
Ligand OCS 1 x OCS

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P3221
Unit cell:
a: 66.4Å b: 66.4Å c: 85.43Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.167 0.165 0.202
Expression system: Escherichia coli

Quick links

Citations

245 review citations

Modification of enhancer chromatin: what, how, and why?
Calo et al. (2013)
244 more

4 mentions without citation

Intrinsic Disorder of the BAF Complex: Roles in Chromatin Remodeling and Disease Development.
El Hadidy et al. (2019)
3 more