› 3ir3

X-ray diffraction
1.99Å resolution

Crystal structure of human 3-hydroxyacyl-thioester dehydratase 2 (HTD2)

Released:
DOI: 10.2210/pdb3ir3/pdb
PDB entry 3ir3 coloured by chain, front view.
PDB entry 3ir3 coloured by chain, side view.
PDB entry 3ir3 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Cocking R, Burgess-Brown N, Pilka E, Muniz J, Krojer T, Chaikuad A, Gileadi O, von Delft F, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, Kavanagh KL, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160972 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hydroxyacyl-thioester dehydratase type 2, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 148 amino acids
Theoretical weight: 16.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P86397 (Residues: 23-168; Coverage: 87%)
Gene name: HTD2
Sequence domains: MaoC like domain
Structure domains: Hotdog Thioesterase

Ligands and Environments

1 bound ligand:
Ligand MLI 1 x MLI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P61
Unit cell:
a: 99.88Å b: 99.88Å c: 77.72Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.172 0.17 0.203
Expression system: Escherichia coli

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