› 3ikn

X-ray diffraction
1.6Å resolution

Crystal structure of galactose bound trimeric human lung surfactant protein D

Released:
DOI: 10.2210/pdb3ikn/pdb
PDB entry 3ikn coloured by chain, front view.
PDB entry 3ikn coloured by chain, side view.
PDB entry 3ikn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterisation of ligand-binding determinants in human lung surfactant protein D: influence of Asp325.
Shrive AK, Martin C, Burns I, Paterson JM, Martin JD, Townsend JP, Waters P, Clark HW, Kishore U, Reid KB, Greenhough TJ
J Mol Biol 394 776-88 (2009)
PMID: 19799916

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152870 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pulmonary surfactant-associated protein D Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 177 amino acids
Theoretical weight: 18.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35247 (Residues: 199-375; Coverage: 50%)
Gene names: COLEC7, PSPD, SFTP4, SFTPD
Sequence domains:
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

2 bound ligands:
Ligand CA 10 x CA
Ligand GAL 3 x GAL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P21
Unit cell:
a: 55.74Å b: 108.58Å c: 55.88Å
α: 90° β: 91.41° γ: 90°
R-values:
R R work R free
0.201 0.201 0.215
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Review: Structural determinants of pattern recognition by lung collectins.
Seaton et al. (2010)
2 more

3 mentions without citation

Computational and experimental prediction of human C-type lectin receptor druggability.
Aretz et al. (2014)
2 more