› 3ikl

X-ray diffraction
3.1Å resolution

Crystal structure of Pol gB delta-I4.

Released:
DOI: 10.2210/pdb3ikl/pdb
PDB entry 3ikl coloured by chain, front view.
PDB entry 3ikl coloured by chain, side view.
PDB entry 3ikl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations.
Lee YS, Kennedy WD, Yin YW
Cell 139 312-24 (2009)
PMID: 19837034

Function and Biology Details

Reaction catalysed: 
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193756 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA polymerase subunit gamma-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 459 amino acids
Theoretical weight: 52.12 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UHN1 (Residues: 1-146, 181-485; Coverage: 93%)
Gene names: MTPOLB, POLG2
Sequence domains: Anticodon binding domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P41
Unit cell:
a: 64.43Å b: 64.43Å c: 260.704Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.257 0.257 0.294
Expression system: Not provided

Quick links

Citations

43 review citations

Mitochondrial DNA mutations in disease and aging.
Park et al. (2011)
42 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)