3ije

X-ray diffraction
2.9Å resolution

Crystal structure of the complete integrin alhaVbeta3 ectodomain plus an Alpha/beta transmembrane fragment

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-138434 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Integrin alpha-V Chain: A
Molecule details ›
Chain: A
Length: 967 amino acids
Theoretical weight: 106.97 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06756 (Residues: 31-997; Coverage: 95%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Structure domains:
Integrin beta-3 Chain: B
Molecule details ›
Chain: B
Length: 695 amino acids
Theoretical weight: 76.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P05106 (Residues: 27-721; Coverage: 91%)
Gene names: GP3A, ITGB3
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3221
Unit cell:
a: 129.87Å b: 129.87Å c: 305.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.244 0.285
Expression system: Spodoptera frugiperda