3iig

X-ray diffraction
2.3Å resolution

Crystal structure of mouse Bcl-xl mutant (F105A) at pH 5.0

Released:
Source organism: Mus musculus
Primary publication:
Structural insights into mouse anti-apoptotic Bcl-xl reveal affinity for Beclin 1 and gossypol.
Biochem Biophys Res Commun 394 515-21 (2010)
PMID: 20206602

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179130 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bcl-2-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 196 amino acids
Theoretical weight: 21.98 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q64373 (Residues: 1-196; Coverage: 84%)
Gene names: Bcl2l, Bcl2l1, Bclx
Sequence domains:
Structure domains: Blc2-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6C1
Spacegroup: P41212
Unit cell:
a: 63.155Å b: 63.155Å c: 110.341Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.236 0.269
Expression system: Escherichia coli