› 3i5w

X-ray diffraction
1.63Å resolution

Crystal structure of human alpha-defensin 5 (mutant R13H)

Released:
DOI: 10.2210/pdb3i5w/pdb
PDB entry 3i5w coloured by chain, front view.
PDB entry 3i5w coloured by chain, side view.
PDB entry 3i5w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5.
de Leeuw E, Rajabi M, Zou G, Pazgier M, Lu W
FEBS Lett 583 2507-12 (2009)
PMID: 19589339

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169582 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HD5(63-94) Chains: A, B
Molecule details ›
Chains: A, B
Length: 32 amino acids
Theoretical weight: 3.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q01523 (Residues: 63-94; Coverage: 43%)
Gene names: DEF5, DEFA5
Sequence domains: Mammalian defensin

Ligands and Environments

2 bound ligands:
Ligand FLC 1 x FLC
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: I222
Unit cell:
a: 48.018Å b: 49.754Å c: 62.355Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.176 0.194
Expression system: Not provided

Quick links

Citations

10 review citations

Paneth cells: maestros of the small intestinal crypts.
Clevers et al. (2013)
9 more