Function and Biology Details
Reaction catalysed:
Nicotinate + H(2)O + NADP(+) = 6-hydroxynicotinate + NADPH
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- 2Fe-2S ferredoxin-type iron-sulfur binding domain
- CO dehydrogenase flavoprotein, C-terminal
- Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily
- Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
- Aldehyde oxidase/xanthine dehydrogenase-like
- [2Fe-2S]-binding domain superfamily
- [2Fe-2S]-binding
- 2Fe-2S ferredoxin, iron-sulphur binding site
11 more domains
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-171095 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Nicotinate dehydrogenase large molybdopterin subunit
Molecule details ›
Chains: A, E
Length: 425 amino acids
Theoretical weight: 46.55 KDa
Source organism: Eubacterium barkeri
UniProt:
Sequence domains:
Length: 425 amino acids
Theoretical weight: 46.55 KDa
Source organism: Eubacterium barkeri
UniProt:
- Canonical:
Q0QLF2 (Residues: 1-425; Coverage: 100%)
Sequence domains:
- Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
- Molybdopterin cofactor-binding domain
Nicotinate dehydrogenase medium molybdopterin subunit
Molecule details ›
Chains: B, F
Length: 330 amino acids
Theoretical weight: 34.51 KDa
Source organism: Eubacterium barkeri
UniProt:
Sequence domains: Molybdopterin cofactor-binding domain
Structure domains: Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain
Length: 330 amino acids
Theoretical weight: 34.51 KDa
Source organism: Eubacterium barkeri
UniProt:
- Canonical: Q0QLF1 (Residues: 1-330; Coverage: 100%)
Sequence domains: Molybdopterin cofactor-binding domain
Structure domains: Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain
Nicotinate dehydrogenase FAD-subunit
Molecule details ›
Chains: C, G
Length: 296 amino acids
Theoretical weight: 32.66 KDa
Source organism: Eubacterium barkeri
UniProt:
Sequence domains:
Structure domains: CO dehydrogenase flavoprotein, C-terminal domain
Length: 296 amino acids
Theoretical weight: 32.66 KDa
Source organism: Eubacterium barkeri
UniProt:
- Canonical: Q0QLF4 (Residues: 1-296; Coverage: 100%)
Sequence domains:
Structure domains: CO dehydrogenase flavoprotein, C-terminal domain
Nicotinate dehydrogenase small FeS subunit
Molecule details ›
Chains: D, H
Length: 160 amino acids
Theoretical weight: 16.99 KDa
Source organism: Eubacterium barkeri
UniProt:
Sequence domains:
Structure domains:
Length: 160 amino acids
Theoretical weight: 16.99 KDa
Source organism: Eubacterium barkeri
UniProt:
- Canonical: Q0QLF3 (Residues: 1-157; Coverage: 100%)
Sequence domains:
Structure domains:
