› 3hm1

X-ray diffraction
2.33Å resolution

Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and estrone ((8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one)

Released:
DOI: 10.2210/pdb3hm1/pdb
PDB entry 3hm1 coloured by chain, front view.
PDB entry 3hm1 coloured by chain, side view.
PDB entry 3hm1 coloured by chain, top view.
Source organisms:
Entry authors: Rajan SS, Kim Y, Vanek K, Liwanag M, Joachimiak A, Greene GL

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136932 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Estrogen receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 253 amino acids
Theoretical weight: 29.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 298-550; Coverage: 43%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: Q9WUI9 (Residues: 686-698; Coverage: 1%)
Gene names: Ncoa2, Tif2

Ligands and Environments

1 bound ligand:
Ligand J3Z 2 x J3Z
1 modified residue:
Ligand CME 6 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 56.267Å b: 82.666Å c: 58.989Å
α: 90° β: 109.18° γ: 90°
R-values:
R R work R free
0.234 0.231 0.289
Expression systems:
  • Escherichia coli
  • Not provided

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