› 3hh8

X-ray diffraction
1.87Å resolution

Crystal Structure and metal binding properties of the lipoprotein MtsA

Released:
DOI: 10.2210/pdb3hh8/pdb
PDB entry 3hh8 coloured by chain, front view.
PDB entry 3hh8 coloured by chain, side view.
PDB entry 3hh8 coloured by chain, top view.
Source organism: Streptococcus pyogenes serotype M1
Primary publication:
Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes.
Sun X, Baker HM, Ge R, Sun H, He QY, Baker EN
Biochemistry 48 6184-90 (2009)
PMID: 19463017

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141260 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Iron ABC transporter substrate-binding lipoprotein MtsA Chain: A
Molecule details ›
Chain: A
Length: 294 amino acids
Theoretical weight: 32.63 KDa
Source organism: Streptococcus pyogenes serotype M1
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A4G4 (Residues: 22-310; Coverage: 100%)
Gene names: M5005_Spy0368, SPy_0453, mtsA
Sequence domains: Zinc-uptake complex component A periplasmic
Structure domains: Nitrogenase molybdenum iron protein domain

Ligands and Environments

1 bound ligand:
Ligand FE 1 x FE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 38.26Å b: 50.077Å c: 157.617Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.172 0.199
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Nutritional immunity beyond iron: a role for manganese and zinc.
Kehl-Fie et al. (2010)
8 more

5 mentions without citation

Manganese uptake and streptococcal virulence.
Eijkelkamp et al. (2015)
4 more