› 3et0

X-ray diffraction
2.4Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 292 amino acids
Theoretical weight: 33.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 235-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand ET0 1 x ET0
Ligand GLC 1 x GLC
1 modified residue:
Ligand CME 2 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: C2
Unit cell:
a: 93.349Å b: 62.451Å c: 119.242Å
α: 90° β: 101.73° γ: 90°
R-values:
R R work R free
0.203 0.2 0.255
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Vemurafenib: the first drug approved for BRAF-mutant cancer.
Bollag et al. (2012)
17 more

4 mentions without citation

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent.
Artis et al. (2009)
3 more