› 3e2i

X-ray diffraction
2.01Å resolution

Crystal structure of Thymidine Kinase from S. aureus

Released:
DOI: 10.2210/pdb3e2i/pdb
PDB entry 3e2i coloured by chain, front view.
PDB entry 3e2i coloured by chain, side view.
PDB entry 3e2i coloured by chain, top view.
Source organism: Staphylococcus aureus
Entry authors: Lam R, Johns K, Battaile KP, Romanov V, Lam K, Pai EF, Chirgadze NY

Function and Biology Details

Reaction catalysed: 
ATP + thymidine = ADP + thymidine 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170944 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidine kinase Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 24.75 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q0H0G9 (Residues: 1-199; Coverage: 100%)
Gene names: CV021_10205, E1948_08760, E1948_11175, EP54_10835, EQ90_06730, FAF17_14390, G6W63_05550, GO814_01045, GO942_06275, GQX37_08600, GZ156_04955, GZ163_05575, NCTC13131_01454, NCTC6133_02880, NCTC7878_02877, NCTC7972_02601, QU38_06270, SAMEA1531744_01983, SAMEA2078260_01913, SAMEA2078588_01884, SAMEA2080344_01802, SAMEA2081063_01817, SAMEA4008575_00654, SAMEA70146418_02217, SAMEA70245418_02350, tdk, tdk_1
Sequence domains: Thymidine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand GOL 1 x GOL
1 modified residue:
Ligand MSE 7 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P4222
Unit cell:
a: 71.621Å b: 71.621Å c: 96.144Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.202 0.237
Expression system: Escherichia coli

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