› 3dlx

X-ray diffraction
2.2Å resolution

Crystal structure of human 3-oxoacid CoA transferase 1

Released:
DOI: 10.2210/pdb3dlx/pdb
PDB entry 3dlx coloured by chain, front view.
PDB entry 3dlx coloured by chain, side view.
PDB entry 3dlx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kavanagh KL, Shafqat N, Yue WW, Picaud S, Murray JW, Maclean EM, von Delft F, Roos AK, Arrowsmith CH, Wikstrom M, Edwards AM, Bountra C, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 489 amino acids
Theoretical weight: 53.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55809 (Residues: 40-520; Coverage: 93%)
Gene names: OXCT, OXCT1, SCOT
Sequence domains: Coenzyme A transferase
Structure domains: Glutaconate Coenzyme A-transferase

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 60.956Å b: 168.492Å c: 95.322Å
α: 90° β: 105.86° γ: 90°
R-values:
R R work R free
0.179 0.178 0.225
Expression system: Escherichia coli BL21(DE3)

Quick links