› 3dgh

X-ray diffraction
1.74Å resolution

Crystal Structure of Drosophila Thioredoxin Reductase, C-terminal 8-residue truncation

Released:
DOI: 10.2210/pdb3dgh/pdb
PDB entry 3dgh coloured by chain, front view.
PDB entry 3dgh coloured by chain, side view.
PDB entry 3dgh coloured by chain, top view.
Source organism: Drosophila melanogaster
Entry authors: Eckenroth BE, Hondal RJ, Everse SJ

Function and Biology Details

Reaction catalysed: 
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161051 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin reductase 1, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 483 amino acids
Theoretical weight: 52.54 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: P91938 (Residues: 111-588; Coverage: 80%)
Gene names: CG2151, GR, Trxr-1, Trxr1
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD
1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P43212
Unit cell:
a: 135.755Å b: 135.755Å c: 132.527Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.2 0.224
Expression system: Escherichia coli

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